| Bioactivity | Conessine dihydrobromide is a steroidal alkaloid and an effective, selective histamine H3 receptor antagonist with Ki values of 5.4, 6.0, 5.7, and 25 nM for human, dog, guinea pig, and rat H3 receptors, respectively. Conessine dihydrobromide exhibits antimalarial activity and can be used in infection-related research[1][2]. |
| CAS | 5913-82-6 |
| Formula | C24H42Br2N2 |
| Molar Mass | 518.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Santora VJ, et al. A new family of H3 receptor antagonists based on the natural product Conessine. Bioorg Med Chem Lett. 2008;18(4):1490-1494 [2]. Kim H, et al. Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression [published online ahead of print, 2018 Feb 1]. J Microbiol Biotechnol. 2018;10.4014.jmb.1711.11009 |
Conessine dihydrobromide
CAS: 5913-82-6 F: C24H42Br2N2 W: 518.41
Conessine dihydrobromide is a steroidal alkaloid and an effective, selective histamine H3 receptor antagonist with Ki va
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