| Bioactivity | Compound E (GMP) is a GMP-grade Compound E (HY-14176). GMP-grade small molecules can be used as adjuvant reagents in cell therapy. Compound E is a γ-secretase inhibitor. Compound E inhibits β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50 values of 0.24, 0.37, and 0.32 nM, respectively[1][2]. |
| CAS | 209986-17-4 |
| Formula | C27H24F2N4O3 |
| Molar Mass | 490.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel γ-secretase inhibitor: implications for presenilin biology[J]. Journal of Biological Chemistry, 2001, 276(48): 45394-45402. [2]. Rasul S, et al. Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells[J]. British journal of cancer, 2009, 100(12): 1879-1888. |
Compound E
CAS: 209986-17-4 F: C27H24F2N4O3 W: 490.50
Compound E (GMP) is a GMP-grade Compound E (HY-14176). GMP-grade small molecules can be used as adjuvant reagents in cel
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