| Bioactivity | Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM[1]. |
| Target | IC50: 36 nM (C1s) |
| In Vivo | Complement C1s-IN-1 (compound (R)-8) (10, 30, 100 mg/kg; p.o.) 抑制人血清诱导的 MAC 形成，并在口服给药后以剂量依赖性方式显示血浆暴露[1]。 Animal Model: |
| Name | Complement C1s-IN-1 |
| Formula | C22H20F2N6O |
| Molar Mass | 422.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ikeda Z, et al. Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway. J Med Chem. 2023 Apr 25. |