Coibamide A_product_DataBase

Bioactivity	Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, shows potent antiproliferative activity. Coibamide A induces autophagosome accumulation via an mTOR-independent mechanism. Coibamide A induces apoptosis. Coibamide A inhibits VEGFA/VEGFR2 expression and suppresses tumor growth in glioblastoma xenografts[1][2].
Invitro	Coibamide A (0.3-1 nM; 3-60 小时) 抑制 MDA-MB-231 乳腺癌细胞的增殖[1]。 Coibamide A (2.3-230 nM; 3 天) 在人 U87-MG 和 SF-295 胶质母细胞瘤细胞中产生浓度和时间依赖性细胞毒性死亡[2]。 Coibamide A (10-300 nM; 72 小时) 以细胞类型特异性的方式诱导 caspase-3/7 的激活和细胞凋亡[2]。 Coibamide A (20 nM; 48 小时) 在抗凋亡的 U87-MG 细胞中诱导自噬体积累[2]。 Cell Proliferation Assay[1] Cell Line:
Name	Coibamide A
CAS	1029227-48-2
Formula	C65H110N10O16
Molar Mass	1287.63
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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