| Bioactivity | Clozic is a potential anti-arthritic agent. |
| Invitro | Clozic is a potential anti-arthritic agent. Concentrations of Clozic greater than 50 μM cause a dose-dependent decrease in the amount of matrix protein synthesized by RHMC cell cultures. Inhibition of RHMC cell culture growth by Clozic occurs in a dose-dependent manner. The anti-proliferative effect of Clozic on RHMC cell growth is reversible. Lactate dehydrogenase (LDH) levels in media taken from RHMC cell cultures exposed to 500 μM Clozic for 3 days do not significantly differ from LDH levels in control cell culture media[1]. |
| Name | Clozic |
| CAS | 22494-47-9 |
| Formula | C17H17ClO3 |
| Molar Mass | 304.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Foster SJ, et al. Anti-proliferative properties of Clozic, a disease-modifying anti-arthritic agent. Biochem Pharmacol. 1983 Feb 1;32(3):461-7. |