| Bioactivity | Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing[1][2]. | ||||||||||||
| Invitro | Closantel, a known anthelmintic drug, is highly specific forfilarial family chitinases compared to those fromprotozoans and the human chitinase, human chitotriosidase[1]. | ||||||||||||
| Name | Closantel | ||||||||||||
| CAS | 57808-65-8 | ||||||||||||
| Formula | C22H14Cl2I2N2O2 | ||||||||||||
| Molar Mass | 663.07 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72. [2]. Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11):3963-72. |
Closantel
CAS: 57808-65-8 F: C22H14Cl2I2N2O2 W: 663.07
Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specif
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