Clomipramine hydrochloride_product_DataBase

Bioactivity	Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
Invitro	Clomipramine hydrochloride can inhibit reuptake of both noradrenaline and 5-HT, although Clomipramine inhibits 5-HT reuptake more strongly than it inhibits noradrenaline reuptake[1].The antidepressant Clomipramine inhibits both venom AChE as well as human serum BChE in a concentration-dependent manner but has no effect on AChE in the rat brain striatum[2]. Clomipramine hydrochloride interferes with the autophagic flux and severely compromises the viability of tumorigenic cells upon cytotoxic stress[3]. Clomipramine hydrochloride reduces autophagy in neuronal primary cultures. Clomipramine (1 and 5 µM) hydrochloride negatively regulates neuronal autophagic pathway in primary cultured cells[3]. Western Blot Analysis[3] Cell Line:
In Vivo	Clomipramine (5-20 mg/kg; i.p) hydrochloride elicits significant hyperglycemia in mice. Clomipramine hydrochloride induces hyperglycemia in mice by blocking the 5-HT2B and/or 5-HT2C receptors, which results in facilitation of adrenaline release. In mice, Clomipramine hydrochloride reduces immobility in the forced swimming test, which is the behavioral model for antidepressants. Clomipramine hydrochloride also inhibits the OCD animal model, marble burying behavior in mice[1]. Clomipramine (20 mg/kg) hydrochloride decreases autophagic flux in murine tissues[3]. Animal Model:
Name	Clomipramine hydrochloride
CAS	17321-77-6
Formula	C19H24Cl2N2
Molar Mass	351.31
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Yumi Sugimoto, et al. The tricyclic antidepressant Clomipramine increases plasma glucose levels of mice. J Pharmacol Sci. 2003 Sep;93(1):74-9. [2]. Mushtaq Ahmed, et al. Comparative study of the inhibitory effect of antidepressants on cholinesterase activity in Bungarus sindanus (krait) venom, human serum and rat striatum. J Enzyme Inhib Med Chem. 2008 Dec;23(6):912-7. [3]. Federica Cavaliere,The tricyclic antidepressant Clomipramine inhibits neuronal autophagic flux. Sci Rep. 2019 Mar 19;9(1):4881.

PeptideDB

Clomipramine hydrochloride

CAS: 17321-77-6 F: C19H24Cl2N2 W: 351.31