| Bioactivity | Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC50=65 nM) by binding to the allosteric site on the regulatory subunit[1]. | ||||||||||||
| Invitro | Clofarabine potently inhibits DNA synthesis. Clofarabine demonstrates strong in vitro growth inhibition and cytotoxic activity (IC50 values=0.028-0.29 μM) in a wide variety of leukaemia and solid tumour cell lines[1]. Clofarabine (0.01-0.1 µM) inhibits proliferation of NB4 cells, which may be related with the down-regulation of Bcl-2 and induction of apoptosis[2]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | Clofarabine | ||||||||||||
| CAS | 123318-82-1 | ||||||||||||
| Formula | C10H11ClFN5O3 | ||||||||||||
| Molar Mass | 303.68 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Clofarabine
CAS: 123318-82-1 F: C10H11ClFN5O3 W: 303.68
Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC50=65 nM
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