| Bioactivity | Clofarabine-5'-diphosphate (Clofarabine-DP) is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) phosphorylation. Clofarabine-5'-diphosphate can be further phorphorylated into Clofarabine-5'-triphosphate, and exhibits cytotoxicity in cancer cells through inhibition of DNA synthesis and DNA repair[1]. |
| CAS | 167620-89-5 |
| Formula | C10H13ClFN5O9P2 |
| Molar Mass | 463.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nagai S, et al., Deoxycytidine kinase modulates the impact of the ABC transporter ABCG2 on clofarabine cytotoxicity. Cancer Res. 2011 Mar 1;71(5):1781-91. |
Clofarabine-5'-diphosphate
CAS: 167620-89-5 F: C10H13ClFN5O9P2 W: 463.64
Clofarabine-5'-diphosphate (Clofarabine-DP) is the metabolite of Clofarabine (HY-A0005) by deoxycytidine kinase (dCK) ph
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