| Bioactivity | Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis with an IC50 of 2.1 μM. Clathrin-IN-4 is a dynamin I GTPase activity inhibitor with an IC50 of 9.1 μM[1]. |
| Name | Clathrin-IN-4 |
| CAS | 762242-59-1 |
| Formula | C17H18Br2N2O |
| Molar Mass | 426.15 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Peter J Cossar, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001. |
Clathrin-IN-4
CAS: 762242-59-1 F: C17H18Br2N2O W: 426.15
Clathrin-IN-4 (compound 8b), a Wiskostatin (HY-12534) analogue, is a potent inhibitor of clathrin mediated endocytosis
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