| Bioactivity | Clathrin-IN-2 is potent inhibitor of clathrin mediated endocytosis (CME) with an IC50 value of 2.3 μM. Clathrin-IN-2 also has inhibitiory for dyn I GTPase with an IC50 value of 7.7 μM[1]. |
| Invitro | Clathrin-IN-2 (Compound 8a) 可以抑制网格蛋白介导的内吞作用，IC50 值为 2.3 μM[1]。Clathrin-IN-2 对 dyn I GTPase 具有抑制作用，IC50 值为 7.7 μM[1]。 |
| Name | Clathrin-IN-2 |
| CAS | 2650733-69-8 |
| Formula | C17H18Br2N2O |
| Molar Mass | 426.15 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Peter J Cossar, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001. |
Clathrin-IN-2
CAS: 2650733-69-8 F: C17H18Br2N2O W: 426.15
Clathrin-IN-2 is potent inhibitor of clathrin mediated endocytosis (CME) with an IC50 value of 2.3 μM. Clathrin-IN-2 al
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