Claramine_product_DataBase

Bioactivity	Claramine is a steroid polyamine with blood-brain barrier permeability. Claramine can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and biological protein-based toxins[1].
Invitro	Claramine (2-20 μM; 20 h) 在人神经母细胞瘤细胞 (SH-SY5Y) 中，低于 10 μM 的浓度下不影响细胞活性。Claramine (2-20 μM; 20 h) 在 HEK293 细胞中不影响细胞活性[1]。Claramine (2.5-10 μM; 20 h) 通过抑制成孔剂蜂毒肽 (HY-P0233) (4 μM; 20 h) 和 α-溶血素 (50 μg/mL; 20 h) 与细胞膜的结合来保护人神经母细胞瘤 (SH-SY5Y) 细胞细胞免受成孔剂蜂毒肽和 α-溶血素的侵害[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Claramine 相关抗体:
CAS	1430194-56-1
Formula	C37H72N4O
Molar Mass	588.99
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kreiser RP, et al. A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents. ACS Chem Neurosci. 2022;13(8):1219-1231.

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