| Bioactivity | Cladophorol A is a cGAS inhibitor that binds to the conserved adenosine nucleobase binding site of cGAS, thereby blocking its activity. At non-cytotoxic concentrations, Cladophorol A effectively inhibits the overactivation of the cGAS-STING pathway with an IC50 of 370 nM. Cladophorol A holds potential for research on inflammatory diseases related to the overactivation of the cGAS-STING pathway[1]. |
| CAS | 146776-30-9 |
| Formula | C13H8O6 |
| Molar Mass | 260.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kissai M, et al. Cladophorol-A is an inhibitor of cyclic GMP-AMP synthase. Bioorg Med Chem Lett. 2025 Jan 1;115:130007. |
Cladophorol A
CAS: 146776-30-9 F: C13H8O6 W: 260.20
Cladophorol A is a cGAS inhibitor that binds to the conserved adenosine nucleobase binding site of cGAS, thereby blockin
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