| Bioactivity | Citrullinated LL-37 5cit is a citrullinated LL-37 (HY-P1222) peptide. The antiviral and antibacterial effects of Citrullinated LL-37 5cit are significantly reduced compared to native LL-37. Citrullinated LL-37 5cit is unable to reduce LPS-mediated release of TNF-α due to a lack of LPS-binding capacity[1]. |
| Name | Citrullinated LL-37 5cit |
| Sequence | Leu-Leu-Gly-Asp-Phe-Phe-{Cit}-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-{Cit}-Ile-Val-Gln-{Cit}-Ile-Lys-Asp-Phe-Leu-{Cit}-Asn-Leu-Val-Pro-{Cit}-Thr-Glu-Ser |
| Shortening | LLGDFF-{Cit}-KSKEKIGKEFK-{Cit}-IVQ-{Cit}-IKDFL-{Cit}-NLVP-{Cit}-TES |
| Formula | C199H324N52O56 |
| Molar Mass | 4341.02 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Casanova V, et al. Citrullination Alters the Antiviral and Immunomodulatory Activities of the Human Cathelicidin LL-37 During Rhinovirus Infection. Front Immunol. 2020 Feb 4;11:85. |
Citrullinated LL-37 5cit
CAS: F: C199H324N52O56 W: 4341.02
Citrullinated LL-37 5cit is a citrullinated LL-37 (HY-P1222) peptide. The antiviral and antibacterial effects of Citrull
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