| Bioactivity | Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[1][2][3]. | ||||||||||||
| Invitro | Citric acid (0-12.5 mM; 24 h) shows antiproliferative activity in a dose dependent manner[3].Citric acid (12.5 mM; 72 h) induces apoptosis and cell cycle arrest at G2/M phase and S phase in a dosedependent manner[3].Citric acid (12.5 mM; 48 h) increases the expression of FAS, BAX, BID, AIF, EndoG, cytochrome c, PARP, GADD153, GRP78 and caspase-3, -8, -9, and decreases of BCL-2 and BCL-Xl[3]. Cell Viability Assay[3] Cell Line: | ||||||||||||
| Name | Citric acid | ||||||||||||
| CAS | 77-92-9 | ||||||||||||
| Formula | C6H8O7 | ||||||||||||
| Molar Mass | 192.12 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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