| Bioactivity | Cisd2 agonist 2 (compound 6) is an orally active Cisd2 activator (EC50=191 nM), while the Cisd2 levels is correlated with nonalcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant toxicity in vivo in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout)[1]. |
| Target | CDGSH iron sulfur domain-containing 2 (Cisd2) |
| Name | Cisd2 agonist 2 |
| CAS | 2916371-59-8 |
| Formula | C14H14N2O4S |
| Molar Mass | 306.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yao CH, et al. Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease. Eur J Med Chem. 2023 Oct 5;258:115583. |
Cisd2 agonist 2
CAS: 2916371-59-8 F: C14H14N2O4S W: 306.34
Cisd2 agonist 2 (compound 6) is an orally active Cisd2 activator (EC50=191 nM), while the Cisd2 levels is correlated wit
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