Cimaterol_product_DataBase

Bioactivity	Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice[1]. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM)[2].
Invitro	Increases in protein synthesis of 12% are found with two myogenic cell lines (L6 and G8-1) on treatment for 6 hr with the beta-adrenergic agonist Cimaterol. The Kd for Cimaterol binding to the L6 beta-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM)[2].Cimaterol induces accumulation of intracellular cAMP and increases the viability of muscle cells during proliferation stage of C2C12 cells. Cimaterol (1 µM) shows a significant increase of cAMP concentration subsequent drug exposure[3]. Cell Proliferation Assay[3] Cell Line:
In Vivo	Cimaterol stimulates skeletal muscle gain in ob/ob mice[1].Feeding Cimaterol to finishing pigs results in a slight improvement in daily gain at the 0.25 mg/kg dietary level[4]. Animal Model:
Name	Cimaterol
CAS	54239-37-1
Formula	C12H17N3O
Molar Mass	219.28
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. H C Walker, et al. Effects of cimaterol, a beta-adrenergic agonist, on energy metabolism in ob/ob mice. Am J Physiol. 1988 Dec;255(6 Pt 2):R952-60. [2]. J M Harper, et al. The effects of beta agonists on muscle cells in culture. Domest Anim Endocrinol. 1990 Oct;7(4):477-84. [3]. Boimpoundi Eunice Flavie Ouali, et al. Beta-agonist drugs modulate the proliferation and differentiation of skeletal muscle cells in vitro. Biochem Biophys Rep. 2021 May 18;26:101019. [4]. W R Walker, et al. Evaluation of cimaterol for finishing swine including a drug withdrawal period. J Anim Sci. 1989 Jan;67(1):168-76.

PeptideDB

Cimaterol

CAS: 54239-37-1 F: C12H17N3O W: 219.28