Chrysotoxine

CAS: 156951-82-5 F: C18H22O5 W: 318.36

Chrysotoxine is an orally active dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes

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Bioactivity	Chrysotoxine is an orally active dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research[1][2].
Invitro	Chrysotoxine (50 nM，24 小时) 降低了 H460 和 H23 的细胞活力，增加了细胞凋亡水平[1]。Chrysotoxine (5-20 nM，72 小时) 抑制了 H460 和 H23 细胞中的 CSC 群体[1]。Chrysotoxine (0-20 nM，过夜) 通过抑制 Src-Akt 活化机制来降低 H460 和 H23 细胞的干性[1]。 0 --> Chrysotoxine 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	Chrysotoxine (25 mg/kg，静脉注射；100 mg/kg，口服；一次) 在 Sprague-Dawley 大鼠模型中快速排泄并且有低生物利用度的特点[2]。Pharmacokinetic parameters of Chrysotoxine in Sprague-Dawley rats[2]Parameters
Name	Chrysotoxine
CAS	156951-82-5
Formula	C18H22O5
Molar Mass	318.36
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Bhummaphan N, et al. Cancer Stem Cell-Suppressing Activity of Chrysotoxine, a Bibenzyl from Dendrobium pulchellum. J Pharmacol Exp Ther. 2018 Feb;364(2):332-346. [2]. Fan J, et al. Determination of chrysotoxine in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:57-62.

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