| Bioactivity | ChoKα inhibitor-4 is a bioisosteric inhibitor of HChoK α1 (IC50=0.66 μM), with inhibitory and antiproliferative effect on cancer cells. ChoKα inhibitor-4 induces apoptosis via mitochondrial pathway, and reduces anti-apoptotic proteins expression[1]. |
| Target | IC50: 0.66 μM (HChoK α1) |
| Invitro | ChoKα inhibitor-4 (化合物 PL55) 对正常人星形胶质细胞 NHA 具有细胞毒性，IC50 为 2.5 μM[1]。ChoKα inhibitor-4 (1, 5 μM; 24 h) 诱导 HeLa 和 A549 细胞在 G1 期细胞周期阻滞[1]。ChoKα inhibitor-4 (1, 5 μM; 24 h) 诱导 HeLa 和 A549 细胞的强线粒体去极化，(1, 5 μM; 48 h 和 72 h) 诱导细胞凋亡[1]。 |
| Name | ChoKα inhibitor-4 |
| Formula | C54H68Br2N4S4 |
| Molar Mass | 1061.21 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Luque-Navarro PM, et al. New bioisosteric sulphur-containing choline kinase inhibitors with a tracked mode of action. Eur J Med Chem. 2023 Jan 15;246:115003. |