Chlorpyrifos_product_DataBase

Bioactivity	Chlorpyrifos is a neurotoxic insecticide that belongs to the class of thionite esters. Chlorpyrifos is also a AChE inhibitor that affects neurological function in insects, humans and other animals. Chlorpyrifos interferes with cell replication and differentiation, ultimately altering synaptic transmission in neurons[1][2][3][4].
Invitro	毒死蜱通过调节脱硫产生毒死蜱氧酮 (CPO)， CPO 对丝氨酸依赖性酯水解酶的活性位点 (如AChE) 具有较高的亲和力[2]。毒死蜱 (3.9-250 μM;24-72 h) 对少突胶质细胞祖细胞具有细胞毒性[3]。毒死蜱 (7.5-480 μM;18 h) 导致细胞核凝结，caspase 3/7 活性升高，(60 μM; 2, 4 h) 还增加中枢胶质细胞血红素氧合酶-1 mRNA 表达，(30, 60, 120 μM;24 h) 增强 H2DCF-DA 强度[3]。 Cell Viability Assay[3] Cell Line:
In Vivo	毒死蜱 (97-276 mg/kg; p.o.; single dose) 有中度急性口服毒性，对大鼠的 50% 的致死剂量 (LD50) 为 97-276 mg/kg[2]。毒死蜱 (1 mg/kg and 5 mg/kg for 1 mL/kg; s.c.; once daily for 3 d) 对大鼠的学习和记忆能力有不良影响，在妊娠 9-12 天处理妊娠大鼠，导致子代行为异常[4]。
Name	Chlorpyrifos
CAS	2921-88-2
Formula	C9H11Cl3NO3PS
Molar Mass	350.59
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Silva MH. Effects of low-dose chlorpyrifos on neurobehavior and potential mechanisms: A review of studies in rodents, zebrafish, and Caenorhabditis elegans. Birth Defects Res. 2020 Apr 1;112(6):445-479. [2]. Choi K, et al. Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes. J Biochem Mol Toxicol. 2006;20(6):279-91. [3]. Saulsbury MD, et al. Chlorpyrifos induces oxidative stress in oligodendrocyte progenitor cells. Toxicology. 2009 May 2;259(1-2):1-9. [4]. Icenogle LM, et al. Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicol Teratol. 2004 Jan-Feb;26(1):95-101.

PeptideDB

Chlorpyrifos

CAS: 2921-88-2 F: C9H11Cl3NO3PS W: 350.59