Chloranthalactone B_product_DataBase

Bioactivity	Chloranthalactone B, a lindenane-type sesquiterpenoid, is a nature product that could be isolated from Chinese medicinal herb Sarcandra glabra. Chloranthalactone B inhibits the production of inflammatory mediators by inhibiting the AP-1 and p38 MAPK pathways[1].
Invitro	Chloranthalactone B (6.25-50 µM; 30 min) 在 LPS 刺激的 RAW264.7 细胞中具有抗炎作用并抑制 NO 产生[1]。Chloranthalactone B (25 and 50 µM; 30 min) 抑制 LPS 处理的 RAW264.7 细胞中诱导型一氧化氮合酶 (iNOS)、环氧合酶-2 (COX-2)、肿瘤坏死因子 α (TNF-α) 和白介素-1β (IL-1β) 在细胞中的表达[1]。Chloranthalactone B (25 and 50 µM; RAW264.7 细胞) 以浓度依赖性方式抑制 LPS 诱导的 AP-1 激活[1]。Chloranthalactone B (25 and 50 µM; RAW264.7 细胞) 抑制 RAW264.7 细胞中 ERK、JNK 和 p38 的磷酸化[1]。 Western Blot Analysis[1] Cell Line:
Name	Chloranthalactone B
CAS	66395-03-7
Formula	C15H16O3
Molar Mass	244.29
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li X, et, al. Anti-Inflammatory Effects of Chloranthalactone B in LPS-Stimulated RAW264.7 Cells. Int J Mol Sci. 2016 Nov 22;17(11):1938.

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