Chitin synthase inhibitor 11_product_DataBase

Bioactivity	Chitin synthase inhibitor 11 is a chitin synthase inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs)[1].
Target	IC50: 0.10 mM (chitin synthase)MIC: 128 μg/mL (C. albicans); 42.67 μg/mL (A. flavus); 64 μg/mL (A. fumigatus); 64 μg/mL (C. neoformans)
Invitro	Chitin synthase inhibitor 11 (compound 9s) (300 ug/mL) has good inhibitory activity against chitin synthase with with an IC50 value of 0.10 mM[1].Chitin synthase inhibitor 11 has antifungal activity for C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 128μg/mL, 42.67 μg/mL, 64 μg/mL and 64 μg/mL, respectively[1].Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro and has additive or synergistic effects combined with fluconazole[1].
Name	Chitin synthase inhibitor 11
Formula	C24H24N4O8
Molar Mass	496.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yajie Xu, et al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723

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