Chitin synthase inhibitor 10_product_DataBase

Bioactivity	Chitin synthase inhibitor 10 is a chitin synthase inhibitor. Chitin synthase inhibitor 10 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs)[1].
Target	IC50: 0.11 mM (chitin synthase)MIC: 64 μg/mL (C. albicans); 256 μg/mL (A. flavus); 128 μg/mL (A. fumigatus); 64 μg/mL (C. neoformans)
Invitro	Chitin synthase inhibitor 10 (compound 9o) (300 ug/mL) has good inhibitory activity against chitin synthase with with an IC50 value of 0.11 mM[1].Chitin synthase inhibitor 10 has antifungal activity for C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 64 μg/mL, 256 μg/mL, 128 μg/mL and 64 μg/mL, respectively[1].Chitin synthase inhibitor 10 is related to the disruption of cell wall architecture[1].
Name	Chitin synthase inhibitor 10
Formula	C24H23Br2N3O6
Molar Mass	609.26
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yajie Xu, et al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723.

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