| Bioactivity | Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor (IC50=0.12 mM). Chitin synthase inhibitor 1 has potent antifungal activity against drug-resistant fungi variants[1]. |
| Target | IC50: 0.12 mM (CHS) |
| Invitro | Chitin synthase inhibitor 1 (compound 5a) shows broad-spectrum antifungal activity (MIC=4 µg/mL in Candidaalbicans (C. albicans) ATCC 76615 and Aspergillus fumigatus (A. fumigatus) GIMCC 3.19; MIC=8 µg/mL in Aspergillus flavus (A. flavus) ATCC 16870 and Crytococcusneoformans (C. neoformans) ATCC 32719)[1].Chitin synthase inhibitor 1 shows antifungal activity against drug-resistant fungi variants (MIC=32 µg/mL in FluconazoleresistantC.albicans ATCC 76615R, Fluconazole-resistant A.fumigatus GIMCC 3.19R, and Fluconazole-resistant C. neoformans ATCC 32719R, Micafunginresistant C.albicans ATCC 76615R’; MIC=16 µg/mL in Fluconazole-resistant A.flavus ATCC 16870R)[1]. |
| Name | Chitin synthase inhibitor 1 |
| Formula | C22H20ClN3O3 |
| Molar Mass | 409.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu H, et al. Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2022, 233:114208. |
Chitin synthase inhibitor 1
CAS: F: C22H20ClN3O3 W: 409.87
Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor (IC50=0.12 mM). Chitin synthase in
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