| Bioactivity | Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity[1][2][3]. | ||||||||||||
| Invitro | Chelidonine (5, 10 and 20 μM; 3-4 days) causes lesions and ventral curling in Dugesia japonica; and significantly decreases Djmcm2 expression at 20 μM but no reduction is observed at 5 and 10 μM; as well as prevents cell cycle progression of stem cells[2].Chelidonine (0-3 μg/mL; 48 h) has cytotoxic activity against melanoma cell lines[3].Chelidonine (1, 2 and 3 μg/mL; 24 h) decreases mitochondrial membrane potential (MMP) in 50% of A-375 cells at 1 and 1.5 μg/mL, and 62% at 3 μg/mL[3]. Cell Cytotoxicity Assay[3] Cell Line: | ||||||||||||
| Name | Chelidonine | ||||||||||||
| CAS | 476-32-4 | ||||||||||||
| Formula | C20H19NO5 | ||||||||||||
| Molar Mass | 353.37 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Chelidonine
CAS: 476-32-4 F: C20H19NO5 W: 353.37
Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G2/M arrest and ind
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