| Bioactivity | Cetuximab powder (C225 powder) is a human IgG1 monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with a Kd of 0.201 nM for EGFR by SPR. Cetuximab has potent antitumor activity[1]. |
| Invitro | Cetuximab powder (C225 powder) 是一种抑制表皮生长因子受体 (EGFR) 的单克隆抗体，SPR 对可溶性 EGFR 的 Kd 为 0.201 nM。通过 ELISA 检测，Cetuximab 在固定 A431 细胞中对 EGFR 的 Kd 也为 0.147 nM[1]。Cetuximab (C225；30 nM) 在处理 8 天后时间依赖性地抑制 SCC-1、SCC-11B、SCC-38 和 SCC-13Y 细胞的增殖。Cetuximab powder (30 nM) 导致 G0/G1 停滞，诱导细胞凋亡，并减少 Rb、p27KIP1、Bcl-2 和 Bax 在 SCC-13Y 细胞中的表达。Cetuximab powder (30 nM) 还可增强放射敏感性并增加 SCC-13Y 细胞中放射诱导的细胞凋亡[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Cetuximab (powder) 相关抗体: |
| In Vivo | Cetuximab powder (C225 powder) (1 毫克/注射) 对肿瘤体积有影响，但对 UT-SCC-14 异种移植物的影响更为明显。在 UT-SCC-14 异种移植物中，Cetuximab powder 可显著降低 EGFR、pEGFR 和 Ki67 的表达。Cetuximab 显著降低 MCT1 和 GLUT1 细胞中的表达，但差异在 UT-SCC-14 异种移植物中更为明显[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 205923-56-4 |
| Transport | Shipping with dry ice. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Goldstein NI, et al. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin Cancer Res. 1995 Nov;1(11):1311-8. [2]. Gustafsson H, et al. EPR Oximetry of Cetuximab-Treated Head-and-Neck Tumours in a Mouse Model. Cell Biochem Biophys. 2017 Jul 29. [3]. Huang SM, et al. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res. 1999 Apr 15;59(8):1935-40. |