Ceralasertib formate_product_DataBase

Bioactivity	Ceralasertib formate is a potent, selective and orally active ATR inhibitor with an IC50 value of 1 nM. Ceralasertib formate inhibits cell viability and induces DNA damage. Ceralasertib formate induces cell senescence. Ceralasertib formate shows antitumor activity[1][2].
Invitro	Ceralasertib formate (0, 0.3, 1 μM; 48 h) 以剂量依赖性方式诱导 A549 细胞衰老[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Ceralasertib formate 相关抗体:
CAS	1352280-98-8
Formula	C20H24N6O2S.xCH2O2
Molar Mass	458.53
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Vendetti FP, et al. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo. Oncotarget. 2015 Dec 29;6(42):44289-305. [2]. Kim HJ, et al. Anti-tumor activity of the ATR inhibitor AZD6738 in HER2 positive breast cancer cells. Int J Cancer. 2017 Jan 1;140(1):109-119.

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