| Bioactivity | Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research[1][2][3]. |
| Invitro | Cenderitide has antiproliferative, anti-fibrotic, and anti-hypertrophic properties[1]. |
| In Vivo | In vivo in normal canines, Cenderitide (10, 50, and 100 ng/kg) is a potent cGMP stimulator that has renal enhancing and cardiac unloading effects, with less reduction of blood pressure[1][4]. |
| Name | Cenderitide |
| CAS | 507289-11-4 |
| Shortening | GLSKGCFGLKLDRIGSMSGLGCPSLRDPRPNAPSTSA (Disulfide bridge:Cys6-Cys22) |
| Formula | C158H263N49O50S3 |
| Molar Mass | 3745.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ichiki T, et al. Natriuretic peptide based therapeutics for heart failure: Cenderitide: A novel first-in-class designer natriuretic peptide. Int J Cardiol. 2019 Apr 15;281:166-171. [2]. Wojta J. Cenderitide: a multivalent designer-peptide-agonist of particulate guanylyl cyclase receptors with considerable therapeutic potential in cardiorenal disease states. Eur Heart J Cardiovasc Pharmacother. 2016 Apr;2(2):106-7. [3]. Lisa C Costello-Boerrigter, et al. Cenderitide (CD-NP), a novel peptide designed to activate both guanylyl cyclase B and A, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure in a proof-of-concept study in patients with chronic heart failure. BMC Pharmacol 11 (Suppl 1), P18 (2011). [4]. Lisy O, et al. Design, synthesis, and actions of a novel chimeric natriuretic peptide: CD-NP. J Am Coll Cardiol. 2008 Jul 1;52(1):60-8. |
Cenderitide
CAS: 507289-11-4 F: C158H263N49O50S3 W: 3745.27
Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP
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