| Bioactivity | Cemadotin (LU103793) is an analogue of Dolastatin 15 (HY-P1126) which is naturally occurring cytotoxic peptides. Cemadotin blocks cells at mitosis, and exhibits Ki value of 1 μM for inhibiting tubulin. Cemadotin can be used to research anticancer[1]. |
| Invitro | Cemadotin (0-100 μM; 35 min) inhibits polymerization dose-dependently in Tubulin-treated Strongylocentrotus purpuratus[1].Cemadotin (0-1000 nM) preferentially suppresses the rate and extent of growing excursions of tubulin, and suppression is dependent upon the drug concentration[1].Cemadotin (0-1 μM) markedly increases the rescue frequency but had little effect on the catastrophe frequency[1].Cemadotin (400 pM~300 nM; 72 h) inhibits cancer cells HEK 293, F9 and HL60[2]. Cell Proliferation Assay[2] Cell Line: |
| Name | Cemadotin |
| CAS | 159776-69-9 |
| Formula | C35H56N6O5 |
| Molar Mass | 640.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Cemadotin
CAS: 159776-69-9 F: C35H56N6O5 W: 640.86
Cemadotin (LU103793) is an analogue of Dolastatin 15 (HY-P1126) which is naturally occurring cytotoxic peptides. Cemadot
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