Cefotiam hydrochloride_product_DataBase

Bioactivity	Cefotiam (SCE-963) hydrochloride is a parenteral cephalosporin antibiotic. Cefotiam hydrochloride has broad-spectrum activity against Gram-positive and Gram-negative bacteria[1][2].
Invitro	Cefotiam (SCE-963; 0-6.25 μg/mL; 8 h) hydrochloride has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849[1].Cefotiam (SCE-963; 0-6.25 μg/mL; 8 h) hydrochloride has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL). All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL[2].
In Vivo	Cefotiam (SCE-963; 12.5-800 mg/kg; i.h.; twice a day for 5 d) hydrochloride can cure urinary tract infection with P. mirabilis in mice to reduce or complete eradicate bacteria in the bladder walls and kidneys[1]. Animal Model:
Name	Cefotiam hydrochloride
CAS	66309-69-1
Formula	C18H25Cl2N9O4S3
Molar Mass	598.55
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *该产品在溶液状态不稳定，建议您现用现配，即刻使用。
Reference	[1]. Iwahi T, et, al. Comparative activities of cefotiam and cefazolin against urinary tract infections with Proteus mirabilis in mice. Antimicrob Agents Chemother. 1980 Aug;18(2):257-63. [2]. Watt B, et, al. In-vitro activity of cefotiam against bacteria of clinical interest. J Antimicrob Chemother. 1982 Nov;10(5):391-5.

PeptideDB

Cefotiam hydrochloride

CAS: 66309-69-1 F: C18H25Cl2N9O4S3 W: 598.55