| Bioactivity | Cdc7-IN-20 (EP-05) is an orally effective and selective Cdc7 inhibitor with IC50 and Ki values of 0.93 and 0.11 nM, respectively. Cdc7-IN-20 has antitumor activity[1]. |
| Invitro | Cdc7-IN-20 (0.5, 1, 2 μM, 24 h) 可抑制 COLO 205 细胞的增殖[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Cdc7-IN-20 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | Cdc7-IN-20 (2, 4, 8 mg/kg, 口服, 连续 3 天) 在 COLO 205 异种移植小鼠模型中具有抗肿瘤作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C15H16N4OS |
| Molar Mass | 300.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fu M, et al. Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin-4-yl) thieno [3, 2-d] pyrimidin-4 (3H)-one derivatives as an orally active antitumor agent. Acta Pharmaceutica Sinica. B, 2024, 14(2): 893. |