| Bioactivity | Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain[1]. |
| Target | Cavα2δ1: 112 nM (Ki);NET: 383 nM (Ki), 67 nM (IC50). |
| Name | Cavα2δ1&NET-IN-2 |
| CAS | 2143586-17-6 |
| Formula | C22H26N6O2S |
| Molar Mass | 438.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Díaz JL, et al. Bicyclic Diazepinones as Dual Ligands of the α2δ-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter. J Med Chem. 2021 Feb 25;64(4):2167-2185. |
Cavα2δ1&NET-IN-2
CAS: 2143586-17-6 F: C22H26N6O2S W: 438.55
Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2
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This product is for research use only, not for human use. We do not sell to patients.