| Bioactivity | Cav 3.1 blocker 1 (compound 12) is a T-type calcium channel blocker with an IC50value of 160 nM for Cav3.1. Cav 3.1 blocker 1 weakly inhibits Cav 3.2 (IC50 of 5000 nM), and shows no inhibition on Cav 3.3 and Cav 1.2 (IC50 of >10000 nM)[1]. |
| CAS | 2158201-04-6 |
| Formula | C26H19F6N3O2 |
| Molar Mass | 519.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bezençon O, et al. Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies. Chimia (Aarau). 2017 Oct 25;71(10):722-729. |
Cav 3.1 blocker 1
CAS: 2158201-04-6 F: C26H19F6N3O2 W: 519.44
Cav 3.1 blocker 1 (compound 12) is a T-type calcium channel blocker with an IC50value of 160 nM for Cav3.1. Cav 3.1 bloc
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