Cathepsin K inhibitor 3_product_DataBase

Bioactivity	Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies[1].
In Vivo	Cathepsin K inhibitor 3 (compound 23) (p.o., 0.03-15 mg/kg, daily, 4 days) results in a significant and dose-dependent reduction in uCTX-I, with an 81% reduction in uCTX-1 levels at 0.3 mg/kg and a slightly more complete reduction at 15 mg/kg in dog[1].The pharmacokinetic parameters of compound 23 Parameters
Name	Cathepsin K inhibitor 3
CAS	1694638-70-4
Formula	C30H31FN4O4S
Molar Mass	562.65
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Anthony T Ginnetti, et al. Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis. Bioorg Med Chem Lett. 2022 Oct 15;74:128927.

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