| Bioactivity | Cathepsin C-IN-4 (compound SF27) is a potent Cathepsin C (Cat C) inhibitor, with an IC50 of 65.6 nM. Cathepsin C-IN-4 also inhibits THP-1 and U937 cell, with IC50 values of 203.4 and 177.6 nM, respectively[1]. |
| Target | IC50: 65.6 ± 1.3 nM (Cat C), 4.13 μM (Cat L), >5 μM (Cat S), >5 μM (Cat B), >5 μM (Cat K) |
| Name | Cathepsin C-IN-4 |
| Formula | C21H14ClF3N4S |
| Molar Mass | 446.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen X, et al. Non-peptidyl non-covalent cathepsin C inhibitoEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo. Eur J Med Chem. 2022 Jun 5;236:114368. |