| Bioactivity | Castanospermine inhibits all forms of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids).target：α- and β-glucosidases.IC 50: 1.2 uM [2] in vitro :Castanospermine, [(1 S,6S,7R,8R,8aR)-1 ,6,7,8-tetrahydroxyoctahydroindolizine]is a potent and specific inhibitor of mammalian and plant α-and β-D-glucosidases in vitro [1] in vivo: Experiments in vivo with castanospermine, an inhibitor of the glucosidases that convert protein N-linked high mannose carbohydrates to complex oligosaccharides, resulted in significant inhibition of tumor growth in nude mice.[3] | ||||||||||||
| Name | Castanospermine | ||||||||||||
| CAS | 79831-76-8 | ||||||||||||
| Formula | C8H15NO4 | ||||||||||||
| Molar Mass | 189.21 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Castanospermine
CAS: 79831-76-8 F: C8H15NO4 W: 189.21
Castanospermine inhibits all forms of α- and β-glucosidases, especially glucosidase l (required for glucoprotein proce
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