| Bioactivity | Caspase-9 Inhibitor III (Ac-LEHD-cmk) is a caspase-9 inhibitor. Caspase-9 Inhibitor III exhibits protective effects on ischemia-reperfusion-induced myocardial injury[1]. | ||||||
| Invitro | Caspase-9 Inhibitor III (0.07-0.105 μM; 灌注 10 min) 显着减弱 I/R 诱导的离体大鼠心脏梗塞大小的增加，冠状动脉废水中乳酸脱氢酶的释放和肌酸激酶的释放，以及凋亡指数[1]。Caspase-9 Inhibitor III (30 μM) 抑制由 MMP-2 诱导的肌钙蛋白 I 水解[2]。 | ||||||
| Name | Caspase-9 Inhibitor III | ||||||
| CAS | 403848-57-7 | ||||||
| Formula | C24H35ClN6O9 | ||||||
| Molar Mass | 587.02 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
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| Reference | [1]. Sodhi RK, et, al. Protective effects of caspase-9 and poly(ADP-ribose) polymerase inhibitors on ischemia-reperfusion-induced myocardial injury. Arch Pharm Res. 2009 Jul;32(7):1037-43. [2]. Castro MM, et, al. Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2. Biochem Pharmacol. 2013 Aug 15;86(4):469-75. |
Caspase-9 Inhibitor III
CAS: 403848-57-7 F: C24H35ClN6O9 W: 587.02
Caspase-9 Inhibitor III (Ac-LEHD-cmk) is a caspase-9 inhibitor. Caspase-9 Inhibitor III exhibits protective effects on i
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