| Bioactivity | Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications[1]. |
| Invitro | Cas9-IN-1 (compound 2) (200 and 500 μM; overnight) helps the E. coli selection strain to survive SpyCas9-induced killing[1]. |
| Name | Cas9-IN-2 |
| CAS | 1030133-34-6 |
| Formula | C21H27N5O4S2 |
| Molar Mass | 477.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lee SW, et al. Identification and Optimization of Novel Small-Molecule Cas9 Inhibitors by Cell-Based High-Throughput Screening. J Med Chem. 2022;65(4):3266-3305. |
Cas9-IN-2
CAS: 1030133-34-6 F: C21H27N5O4S2 W: 477.60
Cas9-IN-2 is a potent Cas9 inhibitor (IC50=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex
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