| Bioactivity | Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells[1]. Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively[2]. |
| Target | IFITM2, IFITM3 IC50: 5.9 μM (hCBS), 12.1 μM (hCSE) |
| Invitro | Caraphenol A (0-50 μM; 8 h) 增强慢病毒载体 (LV) 基因向 HeLa 的传递，但在 HEK293T 细胞中没有观察到相同作用[1]。 Caraphenol A 以依赖于内体转运的方式减少干扰素诱导的跨膜蛋白介导的限制[1]。 Caraphenol A 显著改善了低剂量和高剂量 LV 的造血干细胞 (HSC) 基因传递，而不改变 LV 整合模式[1]。 Caraphenol A (30 μM; 6 h) 促进慢病毒从核内体逃逸[1]。 Caraphenol A (30 μM; 4 h) 改变了 HeLa 细胞中 IFITM2/3 蛋白和晚期内小体的表达和亚细胞定位。Caraphenol A 对晚期核内体的影响取决于 IFITM3 的表达[1]。 |
| In Vivo | Caraphenol A (30 μM; 预处理 4 h) 处理的造血干细胞在小鼠中保持改善的基因标记，而不改变慢病毒整合谱[1]。 |
| Name | Caraphenol A |
| CAS | 354553-35-8 |
| Formula | C42H28O9 |
| Molar Mass | 676.67 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Ozog S, et al. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes. Blood. 2019 Oct 17;134(16):1298-1311. [2]. Niu W, et al. Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe. Medchemcomm. 2016 Nov 15;8(1):198-201. |
Caraphenol A
CAS: 354553-35-8 F: C42H28O9 W: 676.67
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein
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