| Bioactivity | Capsaicin-d7 is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Capsaicin-d7 相关抗体: |
| In Vivo | Capsaicin 通过改变凋亡调节因子 p53、Bcl-2、Bax 和 caspase-3 的蛋白表达来抑制肺癌的发展[3]。Capsaicin (每只小鼠 2 μg，40 μL，注入左后爪足底表面) 可诱导小鼠出现疼痛相关行为[5]。Capsaicin (每只大鼠 10 μL 中 3-30 μg，足底注射) 可诱导大鼠继发性机械超敏反应 (SMH) (临床上用作潜在预测神经性疼痛的模型)[6]。Capsaicin (每只大鼠 25 μL 中 0-500 μg，皮下注射到右侧触须垫中心) 会引起大鼠口面部区域疼痛[7]。大剂量时，辣椒素可能需要在麻醉状态下给药[8][9]。Capsaicin 比 Dihydrocapsaicin (HY-N0361) 更刺激[10]。 Note: 辣味呛人，请注意。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C18H20D7NO3 |
| Molar Mass | 312.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. McNamara FN, et al. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol. 2005 Mar;144(6):781-90. [3]. Anandakumar P, et al. Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice. Int Immunopharmacol. 2013 Jun 6;17(2):254-259. [4]. Shin YH, et al. The Effect of Capsaicin on Salivary Gland Dysfunction. Molecules. 2016 Jun 25;21(7). |