Capravirine

CAS: 178979-85-6 F: C20H20Cl2N4O2S W: 451.37

Capravirine is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) with potent antiviral activity. C

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Bioactivity	Capravirine is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) with potent antiviral activity. Capravirine inhibits replication of HIV-1 strains that are resistant to nucleoside/nucleotide reverse transcriptase inhibitors and other NNRTIs. Capravirine is metabolized by the cytochrome P450 enzyme CYP3A4[1][2].
CAS	178979-85-6
Formula	C20H20Cl2N4O2S
Molar Mass	451.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Bu HZ, et al. Metabolism and excretion of capravirine, a new non-nucleoside reverse transcriptase inhibitor, alone and in combination with ritonavir in healthy volunteers. Drug Metab Dispos. 2004 Jul;32(7):689-98. [2]. Gewurz BE, et al. Capravirine, a nonnucleoside reverse-transcriptase inhibitor in patients infected with HIV-1: a phase 1 study. J Infect Dis. 2004 Dec 1;190(11):1957-61.

Benzyl 2,3-O-Isopropylidene-6-O-trityl-5-keto-α-D-mannofuranose