| Bioactivity | Canfosfamide (hydrochloride) is a prodrug that upon activation by glutathione s-transferase P1-1 (GSTP1-1) yields an anticancer alkylating agent and a glutathione derivative. |
| CAS | 439943-59-6 |
| Formula | C26H41Cl5N5O10PS |
| Molar Mass | 823.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dourado DF, Fernandes PA, Ramos MJ, Mannervik B. Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA). Biochemistry. 2013;52(45):8069-8078. [2]. Satyam A, Hocker MD, Kane-Maguire KA, Morgan AS, Villar HO, Lyttle MH. Design, synthesis, and evaluation of latent alkylating agents activated by glutathione S-transferase. J Med Chem. 1996;39(8):1736-1747. |
Canfosfamide hydrochloride
CAS: 439943-59-6 F: C26H41Cl5N5O10PS W: 823.94
Canfosfamide (hydrochloride) is a prodrug that upon activation by glutathione s-transferase P1-1 (GSTP1-1) yields an ant
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