| Bioactivity | Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.Target: Type-1 angiotensin II receptorCandesartan is generally well tolerated and significantly reduced cardiovascular deaths and hospital admissions for heart failure. Ejection fraction or treatment at baseline did not alter these effects [1]. In rats, TCV-116 inhibited the pressor responses to Ang I, Ang II, and Ang III without an effect on the bradykinin (BK)-induced depressor response. In SHR, the antihypertensive effect of TCV-116 (10 mg/kg) was larger than the maximum antihypertensive effect of enalapril and was not intensified by combination with enalapril. TCV-116 is more effective than enalapril in reducing blood pressure in SHR and 1K, 1C-HR, and that the BK- and/or prostaglandin-potentiating effect of enalapril contributes little to its antihypertensive mechanism in SHR [2]. | ||||||||||||
| Name | Candesartan Cilexetil | ||||||||||||
| CAS | 145040-37-5 | ||||||||||||
| Formula | C33H34N6O6 | ||||||||||||
| Molar Mass | 610.66 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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Candesartan Cilexetil
CAS: 145040-37-5 F: C33H34N6O6 W: 610.66
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist used mainly for the treatment of hypertension.T
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