| Bioactivity | Caloxin 1C2 is a specific PMCA (plasma-membrane Ca2+-ATPases) inhibitor. Caloxin 1C2 is selective for PMCA4 over PMCA1, 2 and 3. The Ki values of Caloxin 1C2 are 2.3 μM for PMCA4 and 21 μM for PMCA1. Caloxin 1C2 dose not cause any significant effects on total Ca2+ transfer. Caloxin 1C2 affects coronary contractility[1][2]. |
| Target | Ki: 2.3±0.3 μM (PMCA4), 21±6 μM (PMCA1) |
| Sequence | Thr-Ala-Trp-Ser-Glu-Val-Leu-Asp-Leu-Leu-Arg-Arg-Gly-Gly-Gly-Ser-Lys-NH2 |
| Shortening | TAWSEVLDLLRRGGGSK-NH2 |
| Formula | C80H134N26O24 |
| Molar Mass | 1844.08 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sillanpää JK, et al. Calcium transfer across the outer mantle epithelium in the Pacific oyster, Crassostrea gigas. Proc Biol Sci. 2018 Nov 14;285(1891):20181676. [2]. Pande J, et al. Functional effects of caloxin 1c2, a novel engineered selective inhibitor of plasma membrane Ca(2+)-pump isoform 4, on coronary artery. J Cell Mol Med. 2008 Jun;12(3):1049-60. |