| Bioactivity | Calcitonin Gene Related Peptide (CGRP) II, rat, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II can be used in the research of cardiovascular diseases[1]. |
| Invitro | Calcitonin Gene Related Peptide (CGRP) II, rat induces vasodilator effects in small-diameter pig left anterior descending (LAD) coronary arteries with an EC50 value of 0.56 nM[1].Calcitonin Gene Related Peptide (CGRP) II, rat relaxes the spontaneous tone in isolated internal anal sphincter (IAS) strips, with an EC50 value of 83 μM[2].Calcitonin Gene Related Peptide (CGRP) II, rat (rβCGRP) inhibits [125I]hαCGRP binding (IC50: 7 nM), and stimulates cAMP accumulation (EC50: 0.56 nM) in the cells co-expressing mRAMP1 (mouse receptor-activity-modifying-protein 1) and rCRLR (rat calcitonin receptor-like receptor)[3].Calcitonin Gene Related Peptide (CGRP) II, rat (rat-βCGRP, 0.01-100 nM) induces endothelium-independent relaxations in the coronary arteries from male and female Sprague-Dawley rats, with an IC50 value of 2.8 nM approximately[4]. |
| Name | Calcitonin Gene Related Peptide (CGRP) II, rat |
| CAS | 99889-63-1 |
| Sequence | Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bridge: Cys2-Cys7) |
| Shortening | SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSKAF-NH2 (Disulfide bridge: Cys2-Cys7) |
| Formula | C163H267N51O50S2 |
| Molar Mass | 3805.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Calcitonin Gene Related Peptide (CGRP) II, rat
CAS: 99889-63-1 F: C163H267N51O50S2 W: 3805.31
Calcitonin Gene Related Peptide (CGRP) II, rat, a CGRP receptor activator, is a potent and long-lasting vasodilator. Cal
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.