| Bioactivity | Calcineurin autoinhibitory peptide TFA is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (calcineurin), with an IC50 of ~10 μM. Calcineurin autoinhibitory peptide TFA could protect neurons from excitatory neuronal death[1][2]. |
| Target | IC50: ~10 μM (calcineurin) |
| Name | Calcineurin autoinhibitory peptide TFA |
| Shortening | ITSFEEAKGLDRINERMPPRRDAMP |
| Formula | C126H206F3N39O41S2 |
| Molar Mass | 3044.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hashimoto Y, et, al. Identification of an autoinhibitory domain in calcineurin. J Biol Chem. 1990 Feb 5; 265(4): 1924-7. [2]. Terada H, et, al. Inhibition of excitatory neuronal cell death by cell-permeable calcineurin autoinhibitory peptide. J Neurochem. 2003 Dec; 87(5): 1145-51. |
Calcineurin autoinhibitory peptide TFA
CAS: F: C126H206F3N39O41S2 W: 3044.34
Calcineurin autoinhibitory peptide TFA is a selective inhibitor of Ca2+/calmodulin-dependent protein phosphatase (c
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