| Bioactivity | Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis[1][2][3][4]. |
| Invitro | Calcimycin (A-23187) hemimagnesium mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner[4]. |
| Name | Calcimycin hemimagnesium |
| CAS | 72124-77-7 |
| Formula | C58H72MgN6O12 |
| Molar Mass | 1069.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Calcimycin hemimagnesium
CAS: 72124-77-7 F: C58H72MgN6O12 W: 1069.53
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium).
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