| Bioactivity | Caf1-IN-1 (Compound 8j) is inhibitor for ribonuclease Caf1 with an IC50 of 0.59 µM. Caf1-IN-1 is also a weak inhibitor for poly(A)-specific ribonuclease (PARN) with IC50 of 23.9 µM[1]. |
| Target | IC50: 0.59 µM (Caf1), 23.9 µM (PARN) |
| CAS | 1807775-88-7 |
| Formula | C18H23N5O3 |
| Molar Mass | 357.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jadhav GP, et al., Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4219-24. |