| Bioactivity | Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53[1]. |
| Invitro | Cadein1 may be a potent anti-cancer agent against human cancers, specifically p53-deficient cancers with functional MMR[1].Cadein1 activates p38 in p53-defective cancer cells with functional MMR to induce cell death. Cadein1 (4 μM) induces p38 phosphorylation in a time-dependent manner in HeLa and HCT116-Ch3/E6 cells [1]. |
| Name | Cadein1 |
| Formula | C33H48F2INO2 |
| Molar Mass | 655.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |