| Bioactivity | Cacaoidin is a glycosylated lantibiotic isolated from a Streptomyces cacaoi strain. Cacaoidin has potent antibacterial activity against Gram-positive pathogens including Clostridium difficile[1]. |
| Name | Cacaoidin |
| Sequence | {d-Ala(N,N-2Me)}-{Dha}-Ala-Pro-Ala-{d-Abu}-Ile-Tyr-Ala-{d-Ala}-Val-{d-Ala}-Ala-{d-Ala}-Ile-{d-Ala}-{d-Abu}-Ala-Ser-Trp-Gly-dehydro-Cys(Thioether: d-Ala1-Ala5, d-Abu18-Cys23, Cys23 is dehydrated to form a double bond between Calpha and carbonyl carbons) |
| Shortening | {d-Ala(N,N-2Me)}-{Dha}-APA-{d-Abu}-IYA-{d-Ala}-V-{d-Ala}-A-{d-Ala}-I-{d-Ala}-{d-Abu}-ASWG-{dehydro-Cys} (Thioether: d-Ala1-Ala5, d-Abu18-Cys23, Cys23 is dehydrated to form a double bond between Calpha and carbonyl carbons) |
| Formula | C107H162N24O32S2 |
| Molar Mass | 2360.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ortiz-López FJ, Carretero-Molina D, Sánchez-Hidalgo M, Martín J, González I, Román-Hurtado F, de la Cruz M, García-Fernández S, Reyes F, Deisinger JP, Müller A, Schneider T, Genilloud O. Cacaoidin, First Member of the New Lanthidin RiPP Family. Angew Chem Int Ed Engl. 2020 Jul 27;59(31):12654-12658. |